Liver and renal biochemical profiles of people with sickle cell disease in Africa: a systematic review and meta‑analysis of case‑control studies

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dc.contributor.authorSilvia Awor
dc.contributor.authorFelix Bongomin
dc.contributor.authorMark Mohan Kaggwa
dc.contributor.authorFrancis Pebalo Pebolo
dc.contributor.authorJackie Epila
dc.contributor.authorGeoffrey Maxwell Malinga
dc.contributor.authorChristine Oryema
dc.contributor.authorProscovia Nnamuyomba
dc.contributor.authorAcaye Ongwech
dc.contributor.authorDavid Musoke
dc.date.accessioned2025-09-01T10:32:48Z
dc.date.available2025-09-01T10:32:48Z
dc.date.issued2024-10-15
dc.descriptionSystematic review registration PROSPERO CRD42022346771
dc.description.abstractBackground: Sickle cell disease (SCD) is a genetic blood disorder characterized by a painful vaso-occlusive crisis due to the sickling of red blood cells in capillaries. Complications often lead to liver and renal dysfunctions, contributing to morbidity and mortality, particularly for children under 5. This systematic review and meta-analysis aimed to evalu ate the liver and renal functions of people with SCD (HbSS) compared to those without it (HbAA) in Africa. Methods: The protocol was registered with PROSPERO (CRD42022346771). We searched PubMed, Embase, Web of Science, and Google Scholar using the keywords “liver function”, “renal function”, “sickle cell disease”, and “Africa” on 6th May 2023 for peer-reviewed articles with abstracts in English. We included case-control studies compar ing SCD (HbSS) with controls without hemoglobinopathies (HbAA). We used the random-effect model to calculate the pooled average values for the blood tests of people with SCD in RStudio version 4.2.2. Systematic review registration PROSPERO CRD42022346771 Results: Overall, 17 articles were analyzed from five African countries involving 1312 people with SCD and 1558 controls. The pooled mean difference of liver enzymes aspartate transaminase (AST) was 8.62 (95% CI − 2.99–20.23, I2 = 97.0%, p < 0.01), alanine transaminase (ALT) 7.82 (95% CI − 0.16–15.80, I2 = 99%, p < 0.01) and alkaline phos phatase (ALP) − 2.54 (95% CI − 64.72 – 59.64, I2 = 99%, p < 0.01) compared to controls. The pooled mean difference for the renal biochemical profiles creatinine − 3.15 (95% CI − 15.02; 8.72, I2=99%, p < 0.01) with a funnel plot asym metry of t = 1.09, df = 9, p = 0.3048 and sample estimates bias of 6.0409. The pooled mean difference for serum urea was − 0.57 (95% CI − 3.49; 2.36, I2 = 99%, p < 0.01), and the estimated glomerular filtration (eGFR) rate was 19.79 (95% CI 10.89–28.68 mL/min/1.73 m2, I2 = 87%, p < 0.01) compared to controls. Conclusion: People with SCD have slightly elevated liver enzymes and estimated glomerular filtration rates com pared to controls in Africa. With all the heterogeneity (I2) > 50%, there was substantial variation in the reported articles’ results.
dc.identifier.citationAwor, S., Bongomin, F., Kaggwa, M. M., Pebolo, F. P., Epila, J., Malinga, G. M., ... & Musoke, D. (2024). Liver and renal biochemical profiles of people with sickle cell disease in Africa: a systematic review and meta-analysis of case-control studies. Systematic Reviews, 13(1), 260.
dc.identifier.otherhttps://doi.org/10.1186/s13643-024-02662-6
dc.identifier.urihttp://hdl.handle.net/20.500.14270/616
dc.language.isoen
dc.publisherBMC
dc.subjectSickle cell
dc.subjectLiver function
dc.subjectRenal function
dc.subjectSystematic review
dc.subjectAfrica
dc.titleLiver and renal biochemical profiles of people with sickle cell disease in Africa: a systematic review and meta‑analysis of case‑control studies
dc.typeArticle

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